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Clicked peptide polymer : ウィキペディア英語版 | Clicked peptide polymer Clicked peptide polymers are poly-triazole-poly-peptide hybrid polymers. They are made of repeating units of a 1,2,3-triazole and an oligopeptide. They can be visualized as an oligopeptide that is flanked at both the C-terminus and N-terminus by a triazole molecule. ==Synthesis==
Clicked peptide polymers are prepared by the azide-alkyne Huisgen cycloaddition also called the click reaction; which is commonly used in bioconjugation reactions to link molecules together with a stable triazole bridge. Peptide based polymers are produced from a cycloaddition variant of step-growth polymerization. The monomers used in this polymerization are oligopeptides with terminal azide and terminal alkyne groups〔van Dijk, M., Nollet, M., Weijers, P., Dechesne, A., van Nostrum, C., Hennink, W., Rijkers, D., and Liskamp, R. (2008), Synthesis and Characterization of Biodegradable Peptide-Based Polymers Prepared by Microwave-Assisted Click Chemistry. Biomacromolecules, 10: 2834-2843〕
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